Selective inhibition of functional lymphocyte subpopulations by ribavirin

Selective inhibition of functional lymphocyte subpopulations by ribavirin.

The present studies were designed to examine the effects of ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide), a broad-spectrum antiviral agent, on the generation of murine antibody responses in vitro. Whereas primary and secondary sheep erythrocyte-specific, plaque-forming cell responses by normal murine spleen cells were enhanced by low concentrations of ribavirin (1 microgram p...

Inhibition of lymphocyte proliferative responses by ribavirin.

When added to cultures of human peripheral blood lymphocytes, ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) inhibited antigen- and mitogen-induced proliferative responses as determined by [3H]thymidine incorporation. Dose-dependent suppressive effects were obtained when concentrations of 5 to 60 microgram of ribavirin per ml were added at culture initiation or up to 96 h there...

ALTERATION OF T-LYMPHOCYTE SUBPOPULATIONS IN SUBACUTE AND CHRONIC BRUCELLOSIS

Human brucellosis is a major health problem in developing countries. A number of patients with human brucellosis do not recover from the acute stage of the disease and pass into the chronic form. Since the pathophysiology of this change is not well understood, we studied the T-cell subsets during the acute, subacute and chronic forms of human brucellosis. In this study we found alterations...

Lymphocyte subpopulations.

Heterogeneity of Lymphocyte Subpopulations

or very minimal in all three, including cell-mediated responses in vivo; the in vitro proliferative response to mitogens, allogeneic cells, or antigens; effector cell function in lymphocyte-antibody lymphocytolytic interaction assays; and in vitro synthesis of IgG, IgA, and IgM. In contrast, mononuclear cells from one of the infants were tested and found capable of lysing both human and chicken...